Sitting for long periods of time can cause weakening and loss of strength of the large muscles in the legs and buttocks. These large muscles are important for walking and maintaining body balance. If these muscles are weak, you are more likely to suffer injuries from falls and injuries during exercise.

Sitting for too long can cause various health problems, including: 
1. Posture disorders
Sitting too long for a long period of time can cause posture problems. 
2. Back pain
Sitting for too long can cause back pain because it puts excess pressure on the spine, back muscles and neck. 
3. Muscle atrophy
Sitting for too long can cause the muscles in the legs and buttocks to become weak because they are rarely moved. 
4. Osteoporosis
Sitting for too long can cause bone density to decrease, putting you at risk of developing osteoporosis. 
5. Diabetes
Sitting for too long can reduce the sensitivity of body cells to insulin so that the burning of carbohydrates and sugar for energy is disrupted. 
6. Obesity
Sitting for too long can reduce the release of molecules that process fat and sugar in the body. 
7. Orthostatic hypotension
Sitting for too long can cause orthostatic hypotension or a sudden drop in blood pressure when standing from a sitting position. 
8. Musculoskeletal disorders
Sitting for too long can cause musculoskeletal disorders in the shoulders, lower back, thighs and knees. 
10. Anxiety and depression
Sitting for too long can increase the risk of anxiety and depression